Vol. 1, Issue 4 (2016)
Ameliorating effect of coconut water on the epithelium and gastric goblet cells of albino wistar rats induced with castor oil
Author(s): Edem GD, Ekanem AU, Mbadugha CC
Abstract: Determination of ameliorating effect of coconut water on the epithelium and gastric goblet cells was evaluated using castor oil induced-diarrhoea in adult Wistar rats. 30 adult male Wistar rats weighing 150 – 250 g were used in this study. The animals were randormly divided into 5 groups of 6 animals each and were fed with Growers feed and clean drinking water ad libitum. Group A was the control and received 5 ml of distilled water, group B received 2ml of castor oil orally, group C received 2ml of castor oil + 30ml of coconut water/kg bd. wt, group D received 2 ml of castor oil + 40 ml of coconut water/kg bd. wt. while group E received 2 ml of castor oil + 4 mg of lope amide/kg bd. wt orally for 5days. The animals were sacrificed for histological studies and determination of serum levels of Na+, Cl-, K+ and HCO3-. Alcian blue stain was used. Data were analysed with window SPSS (version 15.0) using analysis of variance (ANOVA). Result reveals that coconut water given orally to rats in all test groups significantly reduced copious diarrhoea, elevate electrolyte levels in blood and protects the gastric mucosa and other components of the stomach from the irritating stimuli produced by castor oil induced-diarrhoea. It is concluded that coconut water may be useful in the treatment of diarrhoea especially in areas where conventional anti-diarrhoeal drugs like lope amide and others are not readily accessible. Coconut water may be used as an emergency anti-diaarrhoel medium.