Vol. 1, Issue 5 (2016)
Pharmacological studies on toxicological, antidiarrhoeal and vasodilatory activities of Sclerocarya birrea (A. Rich) Hochst (Anacardiaceae) aqueous leaf extract
Author(s): RG Belemtougri, LC Tougouma, Y Ouedraogo, B Bayala
Abstract: This study indicated the pharmacological basis for the use of Sclerocarya birrea in some diseases. In mice, the aqueous leaf extract of S. birrea showed antidiarrhoeal, antisecretory effects against castor oil and magnesium sulphate induced diarrhoea and castor oil induced fluid accumulation at 300 and 500 mg/ kg. The extract was found safe up to tested dose of 3g/ kg. In rat aortic rings, S. birrea demonstrated concentration dependent relaxation of NE and 5-HT induced contractions in endothelium denuded rings. In rings treated with CPA, 2-APB and ryanodine, relaxation was not blocked by CPA, indicating that the extract vasodilating properties are not mediated by this route but by IP3 and ryanodine receptors located in sarcoplasmic reticulum. Our results suggest that S. birrea possesses antidiarrhoeal, antisecretory and vasorelaxation properties mediated through calcium antagonist pathway and probably explains its medicinal use in diarrhoea and hypertension.