International Journal of Biology Research

International Journal of Biology Research


ISSN: 2455-6548

Vol. 2, Issue 2 (2017)

Progeria-The rapid aging disease

Author(s): Arya Lekshmi Kg, Athira Valsalan P, Treesa Pearl
Abstract: The effect of progeria is most commonly seen in children. It is an extremely rare genetic disorder in which symptoms resembling aspects of aging are manifested at a very early age. Progeria is one of several progeroid syndromes caused due to the mutation in the gene Lamin A. Progeria was first described in 1886 by Hutchinson. It was also described independently in 1897 by Gilford. The condition was later named Hutchinson–Gilford progeria syndrome. The word progeria comes from the Greek words "pro" (πρό), meaning "before" or "premature", and "gēras" (γῆρας), meaning "old age”. As there is no complete cure, few people with progeria exceed 13 years of age. At least 90% of patients die from complications of atherosclerosis, such as heart attack or stroke. Mental development is not adversely affected; in fact, intelligence tends to be average to above average although there may not be any successful treatments for progeria itself, there are treatments for the problems it causes, such as arthritic, respiratory, and cardiovascular problems. Sufferers of progeria have normal reproductive development and there are known cases of women with progeria who had delivered healthy off springs.
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