Vol. 3, Issue 1 (2018)
Gastro protective activity of Adansonia digitata L. in ulcer induced rats
Author(s): Dhanasree Basipogu, Nizamuddin Basha Syed, Suresh Kumar Chitta
Abstract: Back ground: Restorative Definition of ulcer is a break in skin or mucous layer with loss of surface tissue, deterioration and the necrosis of epithelial tissue. Ulcers are generally found in within covering of the stomach or small intestine. Stomach Ulcers are the most obvious indication of peptic ulcer illness. Ulcers happen when the thick layer of bodily fluid, which shields the stomach from the stomach related juices, gets diminished. This empowers the stomach related acids to eat the covering tissue of the stomach. There are normally two sorts of Ulcers discovered: stomach and throat or oesophagus Ulcers. Both happen due to radically extraordinary reasons. While oesophageal Ulcer, which is uncommon in nature may occur because of liquor utilization, stomach Ulcers, then again, happen because of an assortment of reasons, for example, way of life factors like smoking, presentation to medications and pharmaceuticals alongside hereditary elements. Our present study aimed to assess the gastro protective activity of Adansonia digitata (Brahmamlika) which is used by the ethnic community as folklore medicine Adansonia digitata L. (Malvaceae) is commonly known as baobab tree native to Africa. Baobab is a multi-purpose tree which offers protection and provides food, clothing and medicine as well as raw material for many useful items, locally known as "Brahmamlika", several plant parts have interesting anti-oxidant and anti-inflammatory properties, and baobab has been used extensively since ancient times in traditional medicine. (De Caluwe E et al., 2010). Adansonia digitata is a folklore plant utilized by tribes of Kurnool district and south Indian Nallamala forest. In this study we assess antiulcer activity and evaluate the effect on the antioxidant system of experimental rats. The leaf of Adansonia digitata was assessed for its gastro defensive action and impact on antioxidant enzymes. Therefore, we found that the AAD1 EAD2 contain fundamentally viable gastro defensive action. It is further planned to study the antioxidant enzymatic studies of GSH, GR, GPx, GST, SOD and CAT in same ulcer incited experimental rats. Subsequently our trial study gives an indescribable imprint to the ethno botanical claims and reported ethno pharmacological actions that Adansonia digitata leaves have a huge restorative potential. 1. Aqueous extract of Adansonia digitata, 2. Ethanol extract of Adansonia digitata Methods: In vivo analysis done in the male Wister albino rats by inducing ulcer and gastro protective studies were carried out Results: The AAD exhibited a dose dependent inhibition percentage of 54.65 preferably at the dose of 200 mg/kg dose. The standard drug Ranitidine showed an inhibition percentage of 77.04.