Vol. 3, Issue 3 (2018)
Assessment of a maternal age on the early embryonic development followed Intracytoplasmic sperm injection (ICSI)
Author(s): Dr. Mohamed Adel, Eman anwar, Mahmoud amin, Sayed bakry
Abstract: The objective of this study aimed to investigate a different maternal age could have effect on the early embryonic development following (ICSI) or not. This study contained 150 ICSI patients divided to 3 groups. The first group includes females aged from 20-29 years old. The second group includes females aged from 30-39 years old. The third group includes females aged from 40-46 years old. The oocytes retrieved from each female were injected by normal sperm morphology >4%, the fertilization rate, cleavage, quality of the embryo, and the rate of blastocyst formation rate are the main outcome measures. The results refer to significant differences in the female’s age, and the number of retrieved oocytes between three groups (p < 0.05). The fertilization rate and cleavage rate are similar in all groups and the proportion of blastocyst formation was significantly decreased in the different groups (22.8% in group A versus 10.4% and 9.2% in groups B and C). In conclusion female age had no effect on the morphology of the embryo day 2 and 3 post insemination and ICSI procedure might make a negative effect on the process of extended culture to blastocyst stage.