Vol. 4, Issue 1 (2019)
Egyptian Purslane (Portulaca oleracea L.) efficacy on amelioration of BMI, PON1 and Irisin in obese rats
Author(s): E El-Zawahry, F Morsey, D Farrag, M Mustafa, M Al-Gebily, K Abdel-Wahhab
Abstract: Obesity is a chronic metabolic disorder that is raised by multiple biological and environmental factors. The objective of this study was to determine the thermogenesis potential of Egyptian purslane seeds (PS) against obesity disorder. Adult male Wistar albino rats (120-150g) were randomly divided into four groups (10 animals each) as follows: group (1) healthy rats fed standard diet and served as control, group (2) animals fed PS-standard diet (20%), group (3) obese rats fed high-fat diet and group (4) obese animals fed PS-high-fat diet (20%). After six weeks of feeding, the results revealed that feeding of obese animals on PS (20% of the high fat diet) succeeded to decline the obesity-induced disorder and manage the weight; this was evidenced by the significant reduction of serum of ALAT, ASAT, urea, creatinine, total cholesterol, triglycerides, LDL, LDH, CK, PON1, TNF-α, leptin and glucose as well as cardio-hepatic MDA and nitric oxide levels coupled with marked improvement in serum HDL and Irisin as well as cardio-hepatic GSH, SOD and catalase. Moreover, the histopathological findings showed marked regenerated. In conclusion, PS, as food supplement, could play a beneficial role in management of obesity and its disorders; this could be exhibited through its bioactive components with multiple pathways.