Synergistic therapy involving curcumin, PYO- bacteriophage, and neem extract to reduce MRSA infection
Shreya Bhandari, Hasmitha Kamineni
Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant form of the gram-positive S. aureus bacterium. HA-MRSA is a major nosocomial pathogen as it is significantly present in healthcare facilities. CA-MRSA infections are those acquired from the community, such as through contact with an infected individual or a carrying fomite. MRSA makes up a portion of normal microbiota in the upper respiratory tract, but can be life-threatening if exposed to previously unexplored parts of the human body. MRSA infection can result in red, warm, swollen, and painful abscesses, which are often mistaken for insect bites, and is accompanied by fever and cellulitis; it can result in life-threatening complications if it enters the bloodstream, since it can result in endocarditis, sepsis, and other such conditions. MRSA is the leading cause of bacterial, respiratory, and skin infections around the globe and numerous patients die of MRSA infection-related complications, making it a paramount issue to solve. In the research provided, the related work is comprised of similar research being done and builds on it to incorporate the novel method being proposed. The proposed method aims to reduce the MRSA infection by utilizing a synergistic therapy involving curcumin, the PYO-bacteriophage cocktail, and neem extract. The future work deals with the need for more experimentation with the proposed method and the consideration of alternative methods that may be more effective, depending upon the conduction of studies upon humans after animal testing.