International Journal of Biology Research

International Journal of Biology Research


International Journal of Biology Research
International Journal of Biology Research
Vol. 1, Issue 2 (2016)

Efficient diagnosis of Mycobacterium tuberculosis (MTB) infections by using membrane secretory proteins of MTB


Gopinath R, Durgadevi P, Gopinath V, Vasanthi K, Elanchezhiyan Manickan

Despite the high incidence of Tuberculosis (TB) in many developing countries, a specific and sensitive method for the diagnosis of TB is still lacking. Mycobacterium tuberculosis (MTB) surrounded by a unique diderm cell envelope that requires a specialized secretion pathway, known as the ESX or type VII secretion (T7S) pathway, to facilitate protein export. Several virulent proteins are secreted via T7S system and utility of such proteins in the MTB diagnosis has been documented. Three such proteins namely PPE41, MPT53, and TB18.5 were found to be highly specific for MTB and their usage as early diagnostic marker has not been reported. We evaluated the early diagnostic property of PPE41, MPT53 and TB18.5 proteins either singly or in combination. From this study we found that a cock tail of all 3 antigen combination detected maximum number of TB cases. Thus PPE41, MPT53 and TB18.5 proteins-based diagnostic methods could be optimized for the better early detection of MTB infections.

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How to cite this article:
Gopinath R, Durgadevi P, Gopinath V, Vasanthi K, Elanchezhiyan Manickan. Efficient diagnosis of Mycobacterium tuberculosis (MTB) infections by using membrane secretory proteins of MTB. International Journal of Biology Research, Volume 1, Issue 2, 2016, Pages 47-52
International Journal of Biology Research