International Journal of Biology Research

International Journal of Biology Research


International Journal of Biology Research
International Journal of Biology Research
Vol. 2, Issue 3 (2017)

CTX-M-15 Extended-Spectrum-Β-Lactamase among Clinical Isolates of Enterobacteriaceae in Abidjan, Côte d’Ivoire


Guessennd KN, Toty AA, Gbonon MC, Dondelinger M, Toé E, Ouattara MB, Tiékoura B, Konan F, Dadié AT, Dosso M, Galleni M

This study aimed the investigation of blaCTX-M-15 gene into 73 enterobacteria collected by the Observatoire de la Résistance des Microorganismes aux Anti-Infecteux en Côte d’Ivoire (ORMICI) in Abidjan. The identification of the species was carried out by standard microbiological methods and confirmed by Maldi-Tof. The antibiotic susceptibility was performed by Vitek-2 and the phenotypic characterization of ESBLs was carried out by double synergy test. The presence of blaCTX-M-15 genes was carried out by PCR followed by sequencing. 56.2% of the strains were ESBL producers. The ESBLs were resistant to cefotaxime (57.5%), ceftazidime (57.5%) and cefepime (54.8%). High resistance to gentamicin (60.3%), ciprofloxacin (60.3%), colistin (79.4%) and cotrimoxazol (60%) was also observed. Carbapenem were the most effective on these strains. 95.1% of ESBLs harbored the blaCTX-M-15 gene. Our study confirms predominance of CTX-M-15 among Enterobacteriaceae throughout the world.
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How to cite this article:
Guessennd KN, Toty AA, Gbonon MC, Dondelinger M, Toé E, Ouattara MB, Tiékoura B, Konan F, Dadié AT, Dosso M, Galleni M. CTX-M-15 Extended-Spectrum-Β-Lactamase among Clinical Isolates of Enterobacteriaceae in Abidjan, Côte d’Ivoire. International Journal of Biology Research, Volume 2, Issue 3, 2017, Pages 05-08
International Journal of Biology Research