Diabetes mellitus has attracted tremendous attention in the field of molecular biology and Biochemistry. Free radicals are very harmful or may be helpful to the body. In certain cases where there is an imbalance between the formation and removal of free radicals which actually cause the oxidative stress. Thus to remove the oxidative stress, antioxidants are required in the body which plays an important role for scavenging the free radicals. As diabetes mellitus is also caused by certain oxidative stress. Antioxidants are required to remove the oxidative stress generated by free radicals and thus helps in curing diabetes mellitus disease both type-1 and type-2. In this review paper all the factors leading to oxidative stress and as well as the factors of antioxidants are mentioned and can be correlated from the entire reading of the paper.