The freshwater fish, Cirrhinus mrigala was exposed to two pesticides i.e., endosulfan and quinolphos. The fishes were exposed to lethal and sublethal concentrations for 21 days and the changes in the carbohydrate metabolism of vital organs such as brain, gill, kidney, liver and muscle were studied.It was observed that the liver is vital organ of carbohydrate metabolism and were drastically affected by both the pesticides.