In recent years, the green pharmaceuticals are receiving much more popularity and importance. The ethnic peoples and tribals are mainly depending on traditional medical system and they pass the information of medicinal plants from one generation to another through orally. The present study highlights traditionally used medicinal plants by the tribal communities in Vilavancode Taluk, Kanyakumari District, Tamilnadu, India. A total of 13 medicinal plants belonging to 9 families were studied. The medicinal plants such as, Abrus precatorius L, Ammomum zerumbet (L), Amaranthus spinosus Linn, Alternanthera sessilis (L), Alpinia calcarata Wild, Aloe vera, Ageratina adenophora, Acorus calamus L, Aerva Lanata Juss x. Schult, Achyranthes aspera Linn, Acalypha fruticosa Forssk and Abutilon indicum (L) were collected. The tribal communities used these medicinal plants to treat snake bite, piles, breathing problems, cough, skin diseases, kidney stone, stomach disorders, anaemia and worm infestation. These medicinal plants are potent source of research and development of novel drugs.