Indian major carp Labeo rohita is used for the various toxicology experiments in life science and medicine field to be consumed major food sources and highly rich proteins present in the Indian major carp. Many toxicology approaches made in lower animals used to toxicants like herbicide, pesticide, insecticide heavy metals etc., Behavior studies, hematology studies, enzyme studies, recovery studies, histology studies, immunological studies, etc., this amassed data may be helpful for the researchers to attention on the significant areas of research yet to be revealed. Widespread information about the animal has been together from various sources like books, Journals and authentic classical texts, etc. Researcher and pharmacologist and toxicological treatment may be helpful security of the whole fish was settled in the criticism.