Documentation of the indigenous knowledge of a primitive tribal group through ethnobotanical studies is important for the conservation of knowledge of traditional medicines should be preserved of various before it is permanently lost. In order to the documentation of the indigenous traditional knowledge and uses of the medicinal plants in the different diseases used by the Paudi Bhuiyan of adjoining villages of the Khandadhar waterfalls of Bonai subdivision of Sundergarh district of Odisha, the present study has been done. The Paudi Bhuiyan resides here are mostly dependent upon natural products for their day to day use and medicinal uses as well. An extensive survey is carried out in the area to highlight some of the major medicinal plants and their uses through an appraisal approach with the local peoples. About 44 plants belonging to 40 genuses studied under 27 families have been found to be used frequently against different diseases.