This study was carried out to evaluate the possible effect of Sphenocentrum jollyanum, Baphia nitida and seeds of Pinus koraiensis and Sildenafil on sodium, potassium, urea and creatinine levels of albino rats. A total of 25 adult rats (220-280g) were bought and randomly divided into 5 groups of 5 rats per group, using water as the control group while four of the 5 groups were administered (oral) with ethanolic extract of Sildenafil, seeds of Pinus koraiensis, Sphenocentrum jollyanum and Baphia nitida. At the end of the experimental period (30days) the blood samples were collected for kidney function tests. The study revealed that the mean urea levels in the test groups administered Sildenafil and the various plant extracts were lower (p>0.05) compared to the control. In the mean levels of creatinine (30seconds and 150 seconds respectively) the study revealed that there was no significant difference (p>0.05) in the test groups compared to that of the control. However, only sildenafil group was lower than the control in the 30 seconds creatinine level and Creatinine levels were significantly higher (p<0.05) in the Spenocentrum jollyanum group compared to the control and Pinus koraiensis group in the 150 seconds creatinine level. Also, the mean sodium and potassium levels in the test groups showed no significant difference (p>0.05) as compared to the control. However sildenafil administered was highest in both sodium and potassium levels. From the experiment, it was observed that the ethanolic extract of Sildenafil, seeds of Pinus koraiensis, Sphenocentrum jollyanum and Baphia nitida, did not show any adverse effect on the kidney function parameters studied over a period of 30days.