Histopathlogical effects of gold nanoparticles on utero placenta of pregnant rat
Othman F Abdelzaher, Ahmed Sabry S Abdoon, Mohamed I Rady, Fathy Elshaer Mohammed, Ahmed BM Mehany
Gold nanoparticles (GNPs)were widely applied in biomedicine as potential probes for imaging, drug-delivery systems and regenerative medicine. However, their applications in clinical research have raised concerns about the adverse effects of (GNPs)on human health and environment.The present study was undertaken to determine the potential histopathological effects of (AuNPs) of different size (10, 25 and 50 nm) on utero placenta of pregnant rats. Gold nanoparticles were intraperitoneally injected at 48 h post pregnancy. Four equal groups of pregnant rats were used; the first one served as a control group, the second received 75 mg/kg/day AuNPs as 10 nm in size, the third group received 75 mg/kg/day AuNPs as 25 nm in size and the forth group received 75 mg/kg/day AuNPs as 50 nm in size. All groups scarified after 15 days from gestation, utero placenta specimens were collected at the end of the experiment for histological examination. AuNPs treated group revealed wide spread histological alterations in the utero placenta structure as myometrium with marked edema with vacuolation,markedly dilated blood vessels,excess glycogen cells with cytolysis of glycogen cells and dilated fetal blood vessels with excess nucleated red cells.
Othman F Abdelzaher, Ahmed Sabry S Abdoon, Mohamed I Rady, Fathy Elshaer Mohammed, Ahmed BM Mehany. Histopathlogical effects of gold nanoparticles on utero placenta of pregnant rat. International Journal of Biology Research, Volume 3, Issue 4, 2018, Pages 06-10