The present study was designed to investigate the possible therapeutic effects of Balanites aegyptiaca (Heglig dates), Persea Americana (Avocado fruit) and Aphanizomenon flos-aquae (AFA) water extracts on some biochemical parameters such as ALAT, ASAT, alkaline phosphatase, acid phosphatase, triglycerides, cholesterol, LDL-cholesterol, HDL-cholesterol, total lipids and risk ratio 1&2 in streptozotocin diabetic rats. The results of the current study recorded a significant increase in serum ALAT, ASAT and ALP enzymes activities in diabetic group in comparison with the negative control group. Also a significant increase was observed in serum triglycerides, cholesterol, LDL-cholesterol, total lipids level and risk ratio 1 &2. On contrast, a significant decrease was recorded in serum ACP enzyme activity, HDL-cholesterol level in diabetic group. Rats treated with Balanites aegyptiaca, Persea Americana and AFA alone or mixed together showed an improvement in these parameters.