This study investigated the survival potential of Callosobruchus maculatus reared on cowpea seeds treated with different concentrations of powder and solvent extracts of the leaf and root bark of Calotropis procera and Parquetina nigrescens. These were with a view to developing a new bio-control of Callosobruchus maculatus. Different concentrations of the powder and solvent extract of the plant materials were prepared and used for survivorship bioassay. The results showed that there was relatively low (5 – 25%) survival of second instar larvae of C. maculatus treated with 5% concentration of ethanolic and methanolic extracts of leaf and root bark of C. procera and P. nigrescens. The adults of C. maculatus treated at 5% concentration of ethanolic and methanolic extracts of leaf and root bark of C. procera and P. nigrescens had no survival except for the ethanolic and methanolic extract of C. procera root bark where 20 and 35% survival were recorded respectively. The study concluded that the leaf and root bark of C. procera and P. nigrescens contained bioactive substances that could reduce survival rate of C. maculatus.