The study was carried out in different hospitals of Allahabad region. Total of 80 hospital waste water samples were subjected to Heterotrophic plate count studies by pour plate method in nutrient agar and incubated at 37℃ for 24 hours. Similarly for selective isolation of bacteria the specimens were cultured in MacConkey Agar Media, SS Agar, Cetrimide Agar, MSA Media. Total of 453 strains were isolated which were further identified as Pseudomonas aeruginosa, Escherichia coli, Salmonella enteric sub. arizonae, Klebsiella pneumoniae, Salmonella enteric sub. enteric, Enterobacter intermedius, Yersinia pseudotuberculosis, Enterobacter sakazakii and Staphylococcus aureus. One isolate from each species were subjected to in-vitro antibiotic susceptibility test by modified Kirby Bauer disk diffusion technique for resistance pattern against Ciprofloxacin, Gentamicin, Amikacin, Choramphenicol, Piperacillin, Amoxicillin, Meropenum, Ceftazidime, Tetracyclin, Nitrofurantoin, Aztreonam and Ampicillin. Heterotrophic plate count of hospital effluents significantly exceeded the standard hetertrophic plate count (p=0.000). Out of nine isolates tested all were multi drug resistant showing resistant to more than four antibiotics except Staphylococcus aureus. Health care liquid waste were laden with MDR bacteria and seemed to pose a huge public health in transfer of such resistance to the bacterial pathogen causing community acquired infections.