Plant metabolites are the clinically curative materials of medicinal plants. Spondias mombin is crucial in folk medicine in Nigeria and all over Africa because it is widely used to treat diseases. The current study investigated the effect of Spondias mombin leaf's aqueous content on the Red Blood Cells of Monosodium Glutamate (MSG) induced fibroid on albino rats. A total of 12 Albino rats were grouped into three groups of 4 rats each. The aqueous extract was orally administered at varying dosages for 28 days at the expiration of which the hematological parameter was carried out. The findings revealed a significant decrease in the red blood cell of the rat (7.24±0.26b) compared to the control group. The study concludes that Spondias mombin leaf extract could be effective in treating fibroid.