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VOL. 6, ISSUE 3 (2021)
Homolgy modelling of hypothetical protein (Apolipoprotein L6)
Authors
Sushma Kumari, Nayan Mehta, Varinder Kumar, Jasmine Dua
Abstract
Apolipoprotein L(Apo L) belongs to the high density lipoprotein family that plays a central role in cholesterol transport.There are six apo L genes located very close to each other on chromosome 22q12 in humans. Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene. It is found that there is a number of proteins related to this family whose structure is unknown till date. I performed homology modelling which is a technique of choice when experimental structure data are not available but three-dimensional coordinates are needed. Chromosome Locus 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia. Using bioinformatics tools and softwares, a homology based 3-D model of hypothetical protein sequence is generated.
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Pages:24-29
How to cite this article:
Sushma Kumari, Nayan Mehta, Varinder Kumar, Jasmine Dua "Homolgy modelling of hypothetical protein (Apolipoprotein L6) ". International Journal of Biology Research, Vol 6, Issue 3, 2021, Pages 24-29
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