Antitumor potential of ovarian and skin extract Singkarak Lake pufferfish (Tetraodon leiurus)

Monica Mulnia Hanif; Wahyu Dwisa Putra; Lira Wilis; Dewi Imelda Roesma; Djong Hon Tjong

Antitumor potential of ovarian and skin extract Singkarak Lake pufferfish (Tetraodon leiurus)

Authors
Monica Mulnia Hanif, Wahyu Dwisa Putra, Lira Wilis, Dewi Imelda Roesma, Djong Hon Tjong

Abstract
Pufferfish contain toxins known as tetrodotoxin (TTX) and saxitoxin (STX). The toxins are highest in the ovaries and skin. Singkarak Lake's Pufferfish (Tetraodon leiurus), with the local name Jabuih fish, is a poisonous fish consumed after the poison is discarded. The purpose of this study was to test the potential of antitumors using ovarian and skin extracts of Pufferfish (Tetraodon leiurus) Singkarak Lake. In addition, the effect of ovarian and skin extracts was tested on the viability of MCF-7 cells by the MTT assay method. Toxicity test showed that ovarian extracts of Pufferfish (Tetraodon leiurus) Singkarak Lake were potentially chemoprevention with an IC₅₀value of 613,164 μg/ml (moderate cytotoxic) while skin extracts of Pufferfish (Tetraodon leiurus) Singkarak Lake with an IC₅₀ value of 1086.97 μg/ml (not cytotoxic).

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