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VOL. 8, ISSUE 2 (2023)
Evaluation of IL-6, PCT and CRP levels in sera of Patients with Pneumonia
Authors
Hafsa Abdul-Redha Abass, Suha Maher Abed, Mayada Noori Iqbal
Abstract
C-reactive protein (CRP) and Procalcitonin (PCT) are biomarkers used in
clinical practice for monitoring pneumonia management. Interleukin-6 (IL-6) is
an important multi-functional pro-inflammatory cytokine and is implicated in
acute inflammatory conditions.
This study aimed at evaluating Interleukin 6, Procalcitonin, and C-reactive
protein levels in patients with pneumonia. Our study included 50 sputum and
blood samples from outpatients who suffered from pneumonia and patients
attending The Tuberculosis Center- Baghdad Medical City from the 1st
of June to the 12th of December 2020. Sputum specimens were cultured
on different media, Gram stained, and were examined using biochemical tests,
including oxidase, catalase, IMVIC test, as well as Kligler Iron agar.
Optochin, bacitracin sensitivity tests, and confirmative tests by Vitek-2
compact system were also performed. In addition, serum IL-6, PCT, and CRP
levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Our study
showed a high increase in IL-6 levels in Gram-negative bacterial pneumonia
compared with Gram-positive pneumonia. Whereas, levels of CRP and PCT were high
in mixed bacterial pneumonia. Taken together, those findings suggest that
bacteria could modify the response to Gram-positive bacterial components, and
different cytokine profiles triggered by Gram-positive and Gram-negative
bacteria might bacterial clearance depending on t differences in the cell wall
structure.
Pages:34-38
How to cite this article:
Hafsa Abdul-Redha Abass, Suha Maher Abed, Mayada Noori Iqbal "Evaluation of IL-6, PCT and CRP levels in sera of Patients with Pneumonia". International Journal of Biology Research, Vol 8, Issue 2, 2023, Pages 34-38
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