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VOL. 9, ISSUE 1 (2024)
Phytochemical profiling and acute toxicity test of Nigella sativa seed and Moringa oleifera leaves
Authors
Bawa Shetaya Gadima, Nura Mohammed, Ismaila Abdullahi
Abstract
This study aimed to investigate the phytochemical constituents and
acute toxicity of Nigella sativa seeds and Moringa oleifera
leaves. Phytochemical screening revealed the presence of alkaloids, flavonoids,
glycosides, and saponins in both plant extracts. Forty eight wistar rats were
used for the acute toxicity study. Twelve rats were grouped into three groups
consisting of three rats each, which received a dosage of 10mg/kg, 100mg/kg and
1000mg/kg in the first phase. Each rat was given a single dose after at least 5
days of adaptation. In addition, a fourth group of three rats was set up as
control group in each phase and animals in the group were not given the
extract. In the second phase, further specific doses (100, 500 and 2000 mg/kg
body weight) of the extract were administered to three rats (one rat per dose)
to further determine the correct LD50 value. The acute toxicity test
of Nigella sativa seeds on wistar rats showed that the aqueous extract
of Nigella sativa seeds has a moderate level of toxicity while Moringa
oleifera leaves have low level of toxicity. The phytochemical constituents
and acute toxicity results suggest that Nigella sativa seeds and Moringa
oleifera leaves have potential therapeutic applications and can be used as
herbal remedies. However, further studies are needed to fully elucidate their
pharmacological and toxicological properties.
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Pages:38-42
How to cite this article:
Bawa Shetaya Gadima, Nura Mohammed, Ismaila Abdullahi "Phytochemical profiling and acute toxicity test of <i>Nigella sativa </i>seed and <i>Moringa oleifera </i>leaves". International Journal of Biology Research, Vol 9, Issue 1, 2024, Pages 38-42
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