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VOL. 10, ISSUE 1 (2025)
Study of the role some biochemical variables in patients with renal failure
Authors
Sheerin Farouq Shaker
Abstract
Chronic renal failure (CRF), or chronic kidney
disease (CKD), is a common condition that is associated with an abnormal renal
function and progressive decline in glomerular filtration rate (GFR). The
association of serum apelin with the progression of CKD is unknown. Therefore,
this study investigated the association of serum apelin levels with end stage
renal disease (ESRD). It aimed at providing additional details on the relationship
between apelin hormone and biochemical markers in patients with ESRD (GFR
<15 ml/min). This observational study involved 70 patients who gradually
progressed to ESRD and 50 healthy as controls. Data were collected from
selected dialysis centers within hospitals during a six-month study (December
2023 to May 2024) in Salahaldin Governorate, Iraq. The demographic, clinical,
and biochemical data of all participants were recorded. Serum apelin was
measured by enzyme-linked immunosorbent assay (ELISA). Blood urea (B-urea),
serum creatinine (S-cr), serum uric acid (S-UA), calcium, potassium, sodium,
serum albumin (S-alb), total protein (T. Prot) were analyzed using an Automated
Biochemical Analyzer. Mean apelin level in patients (161.0± 15.1 pg/mL) was significantly
decreased when compared to the healthy subjects (246.4±26.9 pg/mL). Serum
apelin levels gradually and significantly declined with decreases in the
estimated glomerular filtration rate (eGFR). Serum Apelin showed significant
negative correlations with B-urea (r= - 0.441, p <0.001), S-cr (r = - 0,434,
p < 0.001), S-alb (r= - 0.305, p < 0.01), potassium (r= - 0.395, p <
0.001), S-UA (r= - 0.293, p = 0.014), significant positive correlations with
eGFR (r= 0.465, p < 0.001), calcium (r= 0.389, p < 0.001). This study
could be an important step in the right direction for the accurate detection,
diagnosis and counseling in ESRD.
Pages:26-31
How to cite this article:
Sheerin Farouq Shaker "Study of the role some biochemical variables in patients with renal failure". International Journal of Biology Research, Vol 10, Issue 1, 2025, Pages 26-31
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