Background: Female infertility is linked to hypothyroidism, with the liver playing a crucial role in thyroid hormone metabolism. This study aimed to investigate the impact of thyroid disorders on liver function and their connection to female infertility.

Materials and Method: The study involved 55 infertile women as the test group and 30 non-infertile women as a control group, all aged 18-46, from a private clinical laboratory in Mosul. Blood samples were collected for serum biochemical tests measuring T3, T4, TSH, AST, ALT, and ALK-PH levels. Data analysis included statistical tests such as arithmetic mean, standard deviation, Mann-Whitney U-Test, and linear correlation coefficients.

Results: Findings revealed elevated levels of T4 (43.47), TSH (58), and AST (43.07) at a significance level of 0.05. Conversely, T3 (28.22), ALT (43.19), and ALK-PH (37.15) showed lower values at the same significance level. Total serum bilirubin (TSB) did not exhibit significant differences but showed an inverse relationship with TSH, T4, and T3 levels.