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VOL. 10, ISSUE 3 (2025)
Phytochemical characterization and antioxidant potential of nothapodytes nimmoniana: A Rare source of camptothecin
Authors
Dr. GL Wakle
Abstract
Nothapodytes nimmoniana, a medicinally significant and endangered plant
species, is widely acknowledged as a potent natural source of the anti-cancer
alkaloid camptothecin (CPT). The present study aims to perform a comprehensive
phytochemical characterization of various extracts of N. nimmoniana and
evaluate their antioxidant potential. Preliminary qualitative and quantitative
analyses revealed the presence of key secondary metabolites including
alkaloids, flavonoids, phenols, saponins, and tannins. High-performance thin-layer
chromatography (HPTLC) and high-performance liquid chromatography (HPLC)
techniques confirmed the presence and quantified the concentration of
camptothecin in different plant parts, with the highest yield observed in the
stem bark extract. The antioxidant activity was assessed using DPPH, ABTS, and
FRAP assays, indicating significant free radical scavenging potential. The
strong correlation between phytochemical content and antioxidant activity
suggests that N. nimmoniana not only serves as a valuable reservoir of
camptothecin but also possesses considerable therapeutic potential due to its
antioxidant properties. These findings underscore the importance of conserving
this rare species and harnessing its phytopharmaceutical value in drug
development, particularly for oxidative stress-related diseases.
Pages:8-9
How to cite this article:
Dr. GL Wakle "Phytochemical characterization and antioxidant potential of nothapodytes nimmoniana: A Rare source of camptothecin". International Journal of Biology Research, Vol 10, Issue 3, 2025, Pages 8-9
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