ARCHIVES
VOL. 10, ISSUE 4 (2025)
Impact of Thyroxine on collagen dynamics and tissue remodeling in the Common Indian Toad (Duttaphrynus melanostictus)
Authors
Subhasmita Pattnaik, Gitanjali Mishra, Santhosh Goud
Abstract
Collagen is a fibrous protein that contributes
as a major structural protein in animal skin and bone connective tissue.
Collagen comprises about 30% of the whole body's protein content, especially in
mammals. It is found in the bones, blood vessels, cartilage, corneas, dentin of
teeth, etc. Fibrous tissues such as the skin, tendons, and ligaments are found
as elongated fibrils. It constitutes 1-2% of muscle tissue, a foremost
component of the endomysium. The effect of thyroxine (T4) on
collagen characteristics of Skin (Dorsal & Ventral) & Muscle tissue of
common Indian toad was investigated in the present study. Thyroxine is
essential for both collagen synthesis and matrix metabolism. In the present
study, the solubilities of collagen in salt media, salt soluble/insoluble
collagen ratio, and % of salt solubility decreased in both dorsal and ventral
skin following seven consecutive days of thyroxine administration. Since
salt-soluble collagen is regarded as newly synthesized collagen, our results
show that the salt solubility of skin and muscle collagens decreased following
thyroxine treatment, suggesting that thyroxine decelerates growth by reducing
collagen synthesis. The other biochemical parameters like acid soluble,
insoluble, total collagen, and acid soluble/insoluble ratio and % of acid
solubility increased in both dorsal and ventral skin, except in % acid
solubility in ventral skin. A tissue-specific action of thyroid hormone
administration in the common Indian toad is shown by the results of muscle
tissue where almost all the collagen characteristics decreased though differing
to some extent in degree of response. The role of thyroid hormones in
controlling the physiological processes clearly shows that the anabolic and
catabolic actions depend to a large extent on the dose of the hormone
administrated and are species-specific.
Pages:18-23
How to cite this article:
Subhasmita Pattnaik, Gitanjali Mishra, Santhosh Goud "Impact of Thyroxine on collagen dynamics and tissue remodeling in the Common Indian Toad (<i>Duttaphrynus melanostictus</i>)". International Journal of Biology Research, Vol 10, Issue 4, 2025, Pages 18-23
Download Author Certificate
Please enter the email address corresponding to this article submission to download your certificate.