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VOL. 11, ISSUE 2 (2026)
MCP1-2518 A/G Genetic Polymorphism and Susceptibility to Pulmonary Tuberculosis among Tribes of Jhargram district
Authors
Rituparna De, Jayanta Kumar Kundu
Abstract
Association of variability in the clinical
outcome of persons infected with pulmonary tuberculosis (PTB) is determined by
multiple factors including host genetic variations. MCP-1 has important role in
protective immunity against Mycobacterium tuberculosis, the causative
bacteria for tuberculosis. The motto of the present study is to find out
whether chemokine, gene polymorphisms were associated with susceptibility or
resistance to TB in the tribal population of Jhargram, West Bengal, India.
Monocyte chemoattractant protein-1 (MCP-1) -2518 A/G genetic polymorphisms were
studied by polymerase chain reaction based methods in pulmonary tuberculosis
infected patients (n=56) with normal healthy individuals (n=60). A
significantly increased frequency of GG genotype of MCP1 polymorphism was
observed among PTB patients compared to healthy controls (P<0.05). This
information recommends that GG genotype of MCP1 polymorphism is associated with
susceptibility to PTB in infected patients.
Pages:1-9
How to cite this article:
Rituparna De, Jayanta Kumar Kundu "MCP1-2518 A/G Genetic Polymorphism and Susceptibility to Pulmonary Tuberculosis among Tribes of Jhargram district". International Journal of Biology Research, Vol 11, Issue 2, 2026, Pages 1-9
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