An ethnobotanical survey was conducted to document the ethnomedicinal plants which are used by the Paliyar tribal people in Sadhuragiri forest range (A part of southern Western Ghats) in Virudhunagar district of Tamil Nadu, India. The information on plants was collected by interviewing the Paliyar traditional practitioners. The present study revealed that the plants which are used in traditional systems are mostly collected from the wild resources. There were 150 species of medicinal plants belonging to 66 families were documented in the present study and are mostly used to cure skin diseases, Stomachache, wound, Cough, Asthma, Diarrhoea, Jaundice, Cold, Fever, Ulcer, Headache, Kidney problems, Diabetic, Leprosy, Leucoderma, Snake bite, Body pain, Liver disorders, Gonorrhoea, Nervous disorders, Rheumatism, Anemia, Malaria Sperms counts, Cancer, Eye diseases, Paralysis, Piles and Hernia. The collection and documentation of their empirical knowledge and traditional techniques based on the traditional use of plants is no doubts are markable step keeping in view the fading ethnic traditions and culture. More attempts should be made to authenticate and evaluate the efficacy of these herbs and products used by the Paliyar tribal communities.